On November 20, 2020, the International Space Station marked two decades of continuously hosting humans in space. Construction of the ISS in low Earth orbit began in 1998 and was not deemed ‘complete’ until 2011, however, the first crew of three astronauts and cosmonauts took up residence on the orbiting laboratory in 2000. Twenty years later, more than 200 spacefarers from 18 countries have visited the station, which is now capable of routinely hosting a crew of six for extended stays. During that timeframe, nearly 3000 science experiments have been conducted within the microgravity of the orbiting laboratory.